首页> 外国专利> Derivatives of amidocarboxylic acid, agents for lowering blood glucose, reducing lipid, for improving insulin resistance, anti-inflammatory, for immuno-regulation, for inhibiting aldose reductase, for inhibiting 5-lipoxygenase, for the generation of suppressor of lipid peroxide, to activate ppar, to reduce osteoporosis, and compositions for the therapy or prevention of diabetes mellitus, hyperlipemia, obesity, impaired glucose tolerance, insulin resistance other than igt, liver fatty, diabetic complications, arteriosclerosis, gestational diabetes mellitus, polycystic ovary syndrome, arthroesthesis, rheumatoid arthritis, allergic diseases, asthma, cancer, autoimmune diseases, pancreatitis, and cataracts

Derivatives of amidocarboxylic acid, agents for lowering blood glucose, reducing lipid, for improving insulin resistance, anti-inflammatory, for immuno-regulation, for inhibiting aldose reductase, for inhibiting 5-lipoxygenase, for the generation of suppressor of lipid peroxide, to activate ppar, to reduce osteoporosis, and compositions for the therapy or prevention of diabetes mellitus, hyperlipemia, obesity, impaired glucose tolerance, insulin resistance other than igt, liver fatty, diabetic complications, arteriosclerosis, gestational diabetes mellitus, polycystic ovary syndrome, arthroesthesis, rheumatoid arthritis, allergic diseases, asthma, cancer, autoimmune diseases, pancreatitis, and cataracts

机译：酰胺基羧酸的衍生物，用于降低血糖，减少脂质，改善胰岛素抵抗，消炎，用于免疫调节，用于抑制醛糖还原酶，用于抑制5-脂氧合酶，用于产生脂质过氧化物的抑制剂，激活ppar，以减少骨质疏松症，以及用于治疗或预防糖尿病，高脂血症，肥胖症，糖耐量减低，胰岛素抵抗的胰岛素组合物，肝脂肪，糖尿病并发症，动脉硬化，妊娠糖尿病，多囊卵巢综合征，关节置换，类风湿病的组合物关节炎，过敏性疾病，哮喘，癌症，自身免疫性疾病，胰腺炎和白内障

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摘要

"AMIDOCARBOXYLIC ACID DERIVATIVES, AGENTS TO REDUCE BLOOD GLUCOSE, LIPID REDUCER, TO IMPROVE INSULIN RESISTANCE, ANTI-INFLAMMATORY, TO IMMUNE REGULATION, TO INHIBIT REDUCTASE ALIDOSIS, TO INHIBIT A LIGHTENING LIPID PEROXIDE SUPPRESSOR, TO ACTIVATE PPAR, TO MINIMIZE OSTEOPOROSIS, AND COMPOSITIONS FOR THE THERAPY OR PREVENTION OF DIABETES MELITO, HYPERLIPEMIA, OBESITY, TOLERANCE TO HARMFUL GLUCOSIS, STRENGTH, STRENGTH, RESISTANCE FAT LIVER, DIABETIC COMPLICATIONS, ARTERIOCLESOSIS, GESTATIONAL DIABETES, MELITIS, POLYCYSTIC OVARY SYNDROME, ARTHROSTEITIS, RHEUMATIC ARTHRITIS, ALLERGIC DISEASES, ASMA, AGATARISCUS, . Amidocarboxylic acid derivatives of the formula: [where R1 represents a hydrogen atom, etc .; R2 represents an alkylene group; R3 represents a hydrogen atom, etc .; R4 represents a hydrogen atom, etc .; X represents a substituted or unsubstituted alkyl group, etc .; Y represents an oxygen atom, etc .; Z represents an alkylene group, etc .; and W represents an alkyl group, etc.], its pharmacologically acceptable salts and its pharmacologically acceptable esters are useful as a therapeutic agent and / or preventive agent for diabetes mellitus, hyperlipemia, arteriosclerosis, hypertension, etc.

机译：“酰胺羧酸衍生物，旨在减少血糖，脂质减少剂，以改善胰岛素抵抗，抗炎，调节免疫力，抑制还原性阿迪多斯，抑制脂蛋白样变和胶结蛋白过氧化物。糖尿病利托，高脂血症，肥胖症，耐有害GLUCOSIS，力量，强度为的治疗或预防，抗脂肪肝，糖尿病并发症，ARTERIOCLESOSIS，妊娠糖尿病，MELITIS，多囊卵巢综合征，关节骨炎，风湿性关节炎，过敏性疾病，ASMA，具有下式的酰胺基羧酸衍生物：[其中R1代表氢原子等; R2代表亚烷基; R3代表氢原子等; R4代表氢原子等; X代表取代或未取代的烷基等; Y表示氧原子等; Z表示亚烷基等; W表示烷基等]，其药理学上可接受的盐和药理学上可接受的酯可用作糖尿病，高脂血症，动脉硬化，高血压等的治疗剂和/或预防剂。

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公开/公告号BR9813019A

专利类型
公开/公告日2000-09-05

原文格式PDF
申请/专利权人 SANKYO COMPANY LIMITED;
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申请/专利号BR19989813019
发明设计人 HIROAKI YANAGISAWA;MITSUYA SAKURAI;MAKOTO TAKAMURA;TOSHIHIKO FUJIWARA;
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申请日1998-09-30
分类号C07C233/69;C07C235/42;C07C235/84;C07C237/32;A61K31/165;A61K31/38;A61K31/40;A61K31/415;A61K31/42;A61K31/425;A61K31/44;A61K31/445;A61K31/47;A61K31/535;C07D207/327;C07D209/42;C07D213/56;C07D213/64;C07D213/82;7C07D2B;
国家 BR
入库时间 2022-08-22 01:57:09

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