首页> 外国专利> Compound, pharmaceutical composition, use of a compound, and, processes to treat or reduce the risk of human diseases or conditions, treat or reduce the risk of inflammatory disease and the risk of pain in a person who is suffering, or at risk, of said disease and for the preparation of the compound

Compound, pharmaceutical composition, use of a compound, and, processes to treat or reduce the risk of human diseases or conditions, treat or reduce the risk of inflammatory disease and the risk of pain in a person who is suffering, or at risk, of said disease and for the preparation of the compound

机译:化合物,药物组合物,化合物的用途以及治疗或降低罹患或处于危险中的人的人类疾病或病症的风险,治疗或降低炎症性疾病和疼痛风险的方法所述疾病并用于化合物的制备

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, AND, PROCESSES TO TREAT OR REDUCE THE RISK OF DISEASES OR CONDITIONS OF THE HUMAN BEING, TREAT OR REDUCE THE RISK OF INFLAMMATORY DISEASE AND THE RISK OF PAIN IN A PERSON WHO IS SUFFERING, , OF SUCH DISEASE AND FOR THE PREPARATION OF COMPOUND ". New compounds of formula (I) are provided: where A represents a benzo ring; a six-membered aromatic heterocyclic ring containing 1 to 3 nitrogen atoms; or a five-membered aromatic heterocyclic ring containing 1 to 3 heteroatoms that can be the same or different and are selected from O, N and S; and R ^ 1 ^, R ^ 2 ^, R ^ 3 ^ and X are as defined in the Specification, and pharmaceutically acceptable salts thereof and enantiomers and tautomers thereof; along with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are therefore particularly useful in the treatment and prophylaxis of inflammatory diseases and pain.
机译:“化合物,药物成分,化合物的使用,以及处理或减轻人类疾病或状况的风险的过程,处理或减轻炎症性疾病和疼痛的风险的人, “这种疾病和化合物的制备”。提供了新的式(I)化合物:其中A代表苯并环;含1-3个氮原子的六元芳族杂环;或包含1-3个可以相同或不同的杂原子的五元芳族杂环,所述杂原子选自O,N和S;和R ^ 1 ^,R ^ 2 ^,R ^ 3 ^和X如说明书中所定义,其药学上可接受的盐及其对映异构体和互变异构体;以及其制备方法,包含它们的组合物及其在治疗中的用途。该化合物是一氧化氮合酶的抑制剂,因此特别适用于治疗和预防炎症性疾病和疼痛。

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