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Processes to inhibit thrombus formation in a patient, to maintain or improve vascular patency in a patient, to prevent or minimize myocardial damage associated with post-ischemic reperfusion in an individual, and to improve blood flow in the regional myocardium during post-ischemic reperfusion in an individual, and use of factor vii
Processes to inhibit thrombus formation in a patient, to maintain or improve vascular patency in a patient, to prevent or minimize myocardial damage associated with post-ischemic reperfusion in an individual, and to improve blood flow in the regional myocardium during post-ischemic reperfusion in an individual, and use of factor vii
"PROCESSES TO INHIBIT THE FORMATION OF THROMBONS IN A PATIENT, TO MAINTAIN OR IMPROVE VASCULAR PATIENCE IN A PATIENT, TO AVOID OR MINIMIZE MYOCARDIAL DAMAGE ASSOCIATED WITH POSSCHEMICAL REPREFUSION IN A HOSPITAL, AND HOSPITAL IN HOSPITAL, HOSPITAL, AND HOSPITAL. DURING POSSCHEMICAL REPERFUSION IN AN INDIVIDUAL, AND USE OF FACTOR VII ". The Factor VII catalytic active site is modified to produce a compound that effectively disrupts the blood clotting cascade. The modifications make Factor VIIa substantially unable to activate Factors X or IX in the plasma. The invention relates to new treatment processes and uses of modified Factor VII for the prevention or treatment of myocardial damage associated with post-ischemic reperfusion, to improve blood flow in the reigonal myocardium, during reperfusion, and to maintain or improve vascular patency in a patient, as well as topical application of modified Factor VII in vascular sites susceptible to thrombus formation.
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