首页> 外国专利> Oligonucleotide having sequence id: 22, process to inhibit the synthesis of intercellular adhesion molecules in a cell, oligonucleotide having sequence id: 1, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 20, 21, 23, 24, 25, 26 or 27, process for inhibiting the synthesis of intercellular adhesion molecules in a cell comprising contacting the cell in vitro with an oligonucleotide having sequence no: 1, 3 , 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 20, 21, 23, 24, 25, 26 or 27

Oligonucleotide having sequence id: 22, process to inhibit the synthesis of intercellular adhesion molecules in a cell, oligonucleotide having sequence id: 1, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 20, 21, 23, 24, 25, 26 or 27, process for inhibiting the synthesis of intercellular adhesion molecules in a cell comprising contacting the cell in vitro with an oligonucleotide having sequence no: 1, 3 , 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 20, 21, 23, 24, 25, 26 or 27

机译：具有序列ID：22的寡核苷酸，抑制细胞中细胞间黏附分子合成的方法，具有序列ID：1，3，4，5，7，8，9，10，11，12，13，14，15的寡核苷酸，1、17、20、21、23、24、25、26或27，抑制细胞中细胞间粘附分子合成的方法，包括在体外使细胞与序列号为：1、3、4、5、5的寡核苷酸接触7、8、9、10、11、12、13、14、15、17、20、21、23、24、25、26或27

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Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide or oligonucleotide analog specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.

机译：提供了通过调节细胞间粘附分子的合成或代谢来治疗和诊断适于治疗的疾病的组合物和方法。根据优选的实施方案，提供了可与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮白细胞粘附分子-1的核酸特异性杂交的寡核苷酸和寡核苷酸类似物。寡核苷酸包含足以进行所述特异性杂交的同一性和数量的核苷酸单元。在其他优选的实施方案中，寡核苷酸可与转录起始位点，翻译起始位点，5'非翻译序列，3'非翻译序列和中间序列特异性杂交。公开了通过用与对应于前述蛋白质之一的RNA或DNA特异性杂交的寡核苷酸或寡核苷酸类似物调节细胞粘附蛋白来治疗患有适于治疗性干预的疾病的动物的方法。公开了治疗对调节细胞粘附分子有响应的疾病的方法。

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公开/公告号BR1100617A

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公开/公告日2000-06-13

原文格式PDF
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申请/专利号BR19971100617
发明设计人 C. FRANK BENNETT;CHRISTOPHER K. MIRABELLI;
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申请日1997-05-13
分类号C07H17/00;C07H21/00;C12P19/34;C12Q1/68;A61K31/70;
国家 BR
入库时间 2022-08-22 01:57:27

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