首页> 外国专利> PREPARATION OF HIGH CONCENTRATION AMINO ACID SOLUTION AND PEPTIDE SYNTHESIS USING HIGH CONCENTRATION AMINO ACID SOLUTION

PREPARATION OF HIGH CONCENTRATION AMINO ACID SOLUTION AND PEPTIDE SYNTHESIS USING HIGH CONCENTRATION AMINO ACID SOLUTION

机译:用高浓度氨基酸溶液制备高浓度氨基酸溶液和肽的合成

摘要

PROBLEM TO BE SOLVED: To provide a method for preparing high concentration amino acid solution for synthesis of dipeptides (a lower alkyl ester of aspartylphenylalanine) utilizing protease and a synthesizing method for dipeptide using the high concentration amino acid solution. ;SOLUTION: In the preparation of high concentration substrate solution used for synthesis of peptide by an enzyme reaction, a N-substituted aspartic acid and a lower alkyl ester of phenylalanine and water of the amount that includes the substrates of the concentration higher than the solubility of each substrate to water, and heating at 30°C. The reaction is carried out by adding protease to the high density solution of the amino acid obtained by the prescribed method.;COPYRIGHT: (C)2000,JPO
机译:解决的问题:提供一种利用蛋白酶制备用于合成二肽(天冬氨酰苯丙氨酸的低级烷基酯)的高浓度氨基酸溶液的方法以及使用该高浓度氨基酸溶液的二肽的合成方法。 ;解决方案:在用于通过酶反应合成肽的高浓度底物溶液的制备中,N-取代的天冬氨酸和苯丙氨酸的低级烷基酯和水的含量应包括浓度高于溶解度的底物将每种底物加水,并在30℃下加热。通过将蛋白酶添加到通过规定方法获得的氨基酸的高密度溶液中来进行反应。版权所有:(C)2000,JPO

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