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Preparation of lucas reagent of enhanced utility and its use in synthesis of cycloaliphatic chlorides

机译:具有增强效用的卢卡斯试剂的制备及其在合成环脂族氯化物中的应用

摘要

Gaseous anhydrous hydrogen chloride is introduced into an aqueous solution of zinc chloride under conditions effective to produce a more efficient Lucas reagent than a Lucas reagent made by mixing solid, anhydrous zinc chloride with 38% hydrochloric acid. For example, the reaction rate of such Lucas reagent with levo-menthol is much faster and requires a much shorter reaction period than Lucas reagent formed in the conventional manner from anhydrous, solid zinc chloride and concentrated (38%) hydrochloric acid. Also, the conversion to levo-menthyl chloride was higher when using Lucas reagent formed using gaseous anhydrous hydrogen chloride and aqueous zinc chloride solution. Also, Lucas reagent made in this manner is highly amenable to recycling, and requires only addition thereto of hydrogen chloride to replenish the catalyst for an ensuing run.
机译:在有效产生比通过混合固体无水氯化锌与38%盐酸制得的卢卡斯试剂更有效的条件下,将气态无水氯化氢引入氯化锌水溶液中。例如,这种卢卡斯试剂与左薄荷醇的反应速率比由无水,固态氯化锌和浓(38%)盐酸以常规方式形成的卢卡斯试剂快得多,并且所需的反应时间短得多。另外,当使用由气态无水氯化氢和氯化锌水溶液形成的Lucas试剂时,向左薄荷基氯的转化率更高。而且,以这种方式制得的卢卡斯试剂高度适于再循环,并且仅需要向其中添加氯化氢以补充催化剂以用于随后的操作。

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