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Cells expressing IL-10 receptor and the CRFB4 gene product, an IL- 10 receptor accessory protein
Cells expressing IL-10 receptor and the CRFB4 gene product, an IL- 10 receptor accessory protein
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机译：表达IL-10受体和CRFB4基因产物（IL-10受体辅助蛋白）的细胞
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摘要
The present invention relates to the identification of intracellular signal transduction function for a putative cytokine receptor subunit. In particular, the invention relates to the identification of the signal transduction protein for the interleukin (IL) -10 receptor. Accordingly, the present invention relates to preparing recombinant cells that express the IL-10 receptor and the newly identified IL-10 signal transduction protein, e.g., for use in screening libraries of compounds for IL-10 agonists and antagonists; to restoring IL-10 function to cells in vivo, e. g., via gene therapy; and in addition to chimeric proteins comprising this signal transduction protein to agonize IL-10 activity. In specific examples, cells transfected with both the first chain of the IL-10R and the presently identified second chain, termed herein CRFB4, were able to transduce a signal in response to contact with IL-10.
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