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PROCESS FOR THE ISOLATING METHOD OF ACTIVE COMPONENT IN ANGELICA KEISKEI KOIDZ AND THEIR PHARMACOLOGICAL EFFECTS
PROCESS FOR THE ISOLATING METHOD OF ACTIVE COMPONENT IN ANGELICA KEISKEI KOIDZ AND THEIR PHARMACOLOGICAL EFFECTS
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机译：当归活性成分的分离方法及其药理作用
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摘要
The present invention relates to a method for separating constituents having pharmacological activity from fresh vinegar and their use, and provides a method for separating active ingredients from fresh vinegar, and elucidates the pharmacological action of these constituents based on these pharmacological actions. It is for providing the use of the component.;In the present invention, the ground portion of fresh vinegar is dried and then pulverized, extracted several times with methanol while reflux-cooled in a water bath, and the solvent is removed under reduced pressure to obtain methanol. Subsequently, the methanolic acid was fractionated and silica gel column chromatography was performed to determine luteolin-7-O-β-D-glucoside and luteolin-7-O. -Lutein (luteolin-7-O-rutinoside) is isolated.;Metaolex and leuthelin-7-O-β-D-glucoside separated in this way are reduced by adipose tissue weight, total cholesterol, total lipid, etc. in hyperlipidemia by high fat diet. It is useful as a modifier.
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