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MULTICOMPONENT ANALYSIS METHOD INCLUDING THE DETERMINATION OF A STATISTICAL CONFIDENCE INTERVAL

机译：确定统计置信区间的多分量分析方法

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摘要

A signal processing method in a processor is provided for performing a multicomponent analysis of a signal resulting from a spectral response of a mixture comprising a plurality of spectrally resolvable molecular species. The method provides both a determination of a concentration estimate and a statistical confidence interval for each species. In the method, a data vector d is received from a multichannel detector, data vector d having a length n.sub.c, n.sub.c being the number of detector channels being monitored. A calibration matrix K having n.sub. c rows and n.sub.p columns is provided wherein n. sub.c is larger than n. sub.p, n. sub.p being the number of spectrally resolvable molecular species. Next, a concentration estimate vector c having length n.sub.p is determined. Finally, a confidence interval CI. sub.i for each of the elements of the concentration estimate vector is determined according to the expressionPPCI.sub.i =c.sub.i .+-. (varcovar(c.sub.ii) ). sup.1/2 Q.sub.(cl,nf)PPwhere Q is the critical value of a statistical distribution for a given level of confidence, cl, and a given number of degrees of freedom n.sub.f where n.sub.f =n.sub.c - n.sub. p. The invention further includes a program storage device embodying the method; a DNA sequencing process employing the method; and, an apparatus for carrying out the method.

机译：提供了一种处理器中的信号处理方法，用于对由包含多种可光谱分辨的分子种类的混合物的光谱响应产生的信号进行多成分分析。该方法提供了每种物种的浓度估计值的确定和统计置信区间。在该方法中，从多通道检测器接收数据矢量d，数据矢量d的长度为nc，nc为被监视的检测器通道的数量。具有n的校准矩阵K。提供了c行和n.p列，其中n。 sub.c大于n。子sub.p是光谱可分辨的分子种类的数量。接下来，确定具有长度np的浓度估计矢量c。最后，置信区间CI。根据表达式

Cl.sub.i = c.sub.i--，确定浓度估计矢量的每个元素的sub.i。（varcovar（c.sub.ii））。 sup.1 / 2 Q.sub。（cl，nf）

其中Q是给定置信度cl和给定自由度n的统计分布的临界值.f，其中nf = nc-n.sub。 p。本发明还包括体现该方法的程序存储设备;采用该方法的DNA测序过程;以及用于执行该方法的设备。展开▼

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公开/公告号EP0897568A1

专利类型
公开/公告日1999-02-24

原文格式PDF
申请/专利权人 THE PERKIN-ELMER CORPORATION;
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申请/专利号EP19970924731
发明设计人 SHARAF MUHAMMAD A.;
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申请日1997-05-15
分类号G06F19/00;C12Q1/68;G01N30/86;
国家 EP
入库时间 2022-08-22 02:19:26

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