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BACTERIAL MASS PRODUCTION OF TAXANES AND PACLITAXEL

机译：泰克和帕克沙特的细菌大量生产

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摘要

The present invention relates to a method of obtaining different biologically pure cultures of bacteria isolated from different species of Taxus such as Taxus canadensis, T. brevifolia, T. baccata, T. cuspi-data, and T. hunnewelliana, wherein the bacteria produce in vitro taxanes and paclitaxel, and wherein the bacteria are of the genus Sphingomonas, Bacillus, Pantoea or Curtobacterium. Also, the present invention relates to a method of a bacterial mass production of at least one taxane or paclitaxel. There is also disclosed a novel bacterial taxane. The present invention also relates to the use of different biologically pure cultures of bacteria isolated from different species of Taxus, wherein the bacteria are able to biotransform pro-taxanes. There is also provided a process for improving taxanes and paclitaxel production of taxanes and paclitaxel producing bacteria which include culturing bacteria in the presence of a mutagenic agent for a period a time sufficient to allow mutagenesis. There is disclosed two new mutated bacterial which have an increased yield of pro-taxane biotransformation.

机译：本发明涉及一种获得从不同种类的红豆杉分离的细菌的不同生物学纯的培养物的方法，所述细菌例如加拿大红豆杉，短叶苜蓿，baccata，T.cuspi-data和T.hunnewelliana，其中所述细菌产生于紫杉烷和紫杉醇，其中细菌是鞘氨醇单胞菌，芽孢杆菌，泛菌或弯杆菌属。另外，本发明涉及细菌大量生产至少一种紫杉烷或紫杉醇的方法。还公开了新型细菌紫杉烷。本发明还涉及从不同种类的红豆杉分离的细菌的不同生物学纯培养物的用途，其中所述细菌能够生物转化紫杉烷。还提供了改善紫杉烷和紫杉醇生产紫杉烷和紫杉醇的细菌的方法，该方法包括在诱变剂存在下培养细菌足以允许诱变的时间。公开了两种新的突变细菌，它们具有增加的紫杉烷生物转化产量。

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公开/公告号WO9932651A1

专利类型
公开/公告日1999-07-01

原文格式PDF
申请/专利权人 BCM DEVELOPPEMENT INC.;PAGE MICHEL;LANDRY NATHALIE;BOISSINOT MAURICE;HELIE MARIE-CLAUDE;HARVEY MARIO;GAGNE MARTIN;
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申请/专利号WO1998CA01150
发明设计人 PAGE MICHEL;HARVEY MARIO;LANDRY NATHALIE;HELIE MARIE-CLAUDE;BOISSINOT MAURICE;GAGNE MARTIN;
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申请日1998-12-18
分类号C12P17/02;C12N3/00;C12N1/00;C12N15/01;C12N1/20;C12P7/62;C12P7/26;
国家 WO
入库时间 2022-08-22 02:21:15

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