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Production of recombinant peptides as natural hydrophobic peptide analogues
Production of recombinant peptides as natural hydrophobic peptide analogues
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机译：生产重组肽作为天然疏水肽类似物
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摘要
A method for secreting a biologically active recombinant peptide as an analogue of a natural peptide having at least one hydrophobic region, by culturing cells transformed by a nucleic acid construct comprising elements for the expression and secretion of said peptide by the cell, and a sequence coding for a peptide with an amino acid sequence that differs from the natural peptide sequence in that it has at least one modification in a non-transmembrane hydrophobic region of the peptide; and by recovering the peptide and/or cells carrying said recombinant peptide. The resulting recombinant peptide, a corresponding DNA sequence, and a bacterium containing same, are also disclosed.
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