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Method for producing, by plant cells, alpha1-antitrypsin and its alleles, and products containing the resulting alpha1-antitrypsin
Method for producing, by plant cells, alpha1-antitrypsin and its alleles, and products containing the resulting alpha1-antitrypsin
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机译：由植物细胞生产α1-抗胰蛋白酶及其等位基因的方法，以及含有所得α1-抗胰蛋白酶的产物的方法
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摘要
he invention concerns a method for producing alpha 1-antitrypsin ( alpha 1-AT), or alleles thereof characterised in that it consists in: (i) introducing in the monocotyledon plant cells, a nucleic acid comprising a sequence coding for alpha 1-antitrypsin ( alpha 1-AT) or for an allele thereof, the alleles being differentiated from natural human alpha 1-AT by one or several substitution(s), deletion(s) or insertion(s) of amino acids, and optionally a sequence coding for a selective agent; (ii) selecting the cells having integrated the nucleic acid in stable manner; (iii) propagating the transformed cells in culture, or regeneration of entire chimerical or transgenic plants; (iv) recuperating and optionally purifying the resulting alpha 1-antitrypsin or its alleles.
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