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Peptide derivatives for use in the treatment of MHC class II dependent t-cell mediated autoimmune or inflammatory disease, pharmaceutical composition comprising the same, and process for manufacture of the same
Peptide derivatives for use in the treatment of MHC class II dependent t-cell mediated autoimmune or inflammatory disease, pharmaceutical composition comprising the same, and process for manufacture of the same
The invention concerns pharmaceutically useful peptide derivatives of the formula I, P-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-Q, in which P,-AA1, AA2, AA3, AA4, AA5, AA6, AA7, AA8, and Q have the various meanings defined herein and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T- cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.
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