首页> 外国专利> Method for inhibiting photoaging of human skin is not damaged by UVB Radiation through Synthesis inhibitors and / or activity of NMP and use of these inhibitors in injectionTo prevent this from mediamneteos envejecimient

Method for inhibiting photoaging of human skin is not damaged by UVB Radiation through Synthesis inhibitors and / or activity of NMP and use of these inhibitors in injectionTo prevent this from mediamneteos envejecimient

机译:抑制人体皮肤光老化的方法不受合成抑制剂和/或NMP活性的UVB辐射的损害,并且在注射中使用这些抑制剂可以防止这种情况发生。

摘要

A method for inhibiting photoaging of human skin is not damaged due to ultraviolet B (UVB) radiationCharacterized in that it comprises: Providing at least one inhibitor of (a) the activity of the MMPs inducible by UVB RadiationIn the skin; (b) one of the following: Transcription Factors ap-1 and NF kB, or both; and (c) at least one of the Protein Kinases or vinculadoras GTP,Involved in the Activation and / or production of Jun and FOS Proteins that comprise the AP - 1; and topical Administration of this inhibitor in a suitable vehicle to the skin prior to DecHas Exposed, in an amount sufficient to inhibit the production or activity of the MMPs inducible by UVB, one of the following: The ap-1 and NF kB, or bothOr at least one of the Protein Kinases vinculadoras GTP or involved in the Activation and / or production of Jun and FOS Proteins.
机译:一种抑制人皮肤光老化的方法,其不会因紫外线B(UVB)辐射而受损,其特征在于包括:提供至少一种抑制剂,用于(a)在皮肤中由UVB辐射诱导的MMP活性。 (b)以下之一:转录因子ap-1和NF kB,或两者兼而有之; (c)参与构成AP-1的Jun和FOS蛋白的活化和/或生产的至少一种蛋白激酶或葡萄球菌GTP;在DecHas暴露之前在适当的媒介物中和在皮肤上局部施用这种抑制剂,其量应足以抑制UVB诱导的MMP的产生或活性,其中之一是ap-1和NF kB,或两者兼有或至少一种vinculadoras GTP蛋白激酶或参与Jun和FOS蛋白的活化和/或生产。

著录项

  • 公开/公告号CO4770951A1

    专利类型

  • 公开/公告日1999-04-30

    原文格式PDF

  • 申请/专利权人 THE UNIVERSITY OF MICHIGAN;

    申请/专利号CO19970001933

  • 发明设计人 VOORHEES JOHN J;FISHER GARY J;

    申请日1997-01-17

  • 分类号A61K7/42;

  • 国家 CO

  • 入库时间 2022-08-22 02:28:01

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