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首页> 外国专利> Reinforcing preparations of host and migrant defense mechanisms with single peak water-soluble b-glycan methods to produce a reinforcing preparation of host defense meanisms to prevent infection in a mammal to stimulate wound repair and healing and to stimulate the proliferation of platelets pharmaceutical composition and method for treating infection in mammals

Reinforcing preparations of host and migrant defense mechanisms with single peak water-soluble b-glycan methods to produce a reinforcing preparation of host defense meanisms to prevent infection in a mammal to stimulate wound repair and healing and to stimulate the proliferation of platelets pharmaceutical composition and method for treating infection in mammals

机译：用单峰水溶性b-聚糖方法增强宿主和迁移防御机制的制剂，以产生宿主防御均质的增强制剂，以防止哺乳动物感染以刺激伤口修复和愈合并刺激血小板的增殖药物组合物和方法用于治疗哺乳动物的感染

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PCT No. PCT/US93/07904 Sec. 371 Date Jan. 26, 1995 Sec. 102(e) Date Jan. 26, 1995 PCT Filed Aug. 20, 1993 PCT Pub. No. WO94/04163 PCT Pub. Date Mar. 3, 1994The present invention relates to neutral, aqueous soluble beta -glucans which exert potent and specific immunological effects without stimulating the production of certain cytokines, to preparations containing the novel beta -glucans, and to a novel manufacturing process therefor. The neutral, aqueous soluble beta -glucan preparation has a high affinity for the beta -glucans receptor of human monocytes and retains two primary biological (or immunological) activities, (1) the enhancement of microbicidal activity of phagocytic cells, and (2) monocyte, neutrophil and platelet hemopoietic activity. Unlike soluble glucans described in the prior art, the neutral, aqueous soluble beta -glucans of this invention neither induces nor primes IL-1 beta and TNF alpha production in vitro and in vivo. Safe and efficacious preparations of neutral, aqueous soluble beta -glucan of the present invention can be used in therapeutic and/or prophylactic treatment regimens of humans and animals to enhance their immune response, without stimulating the production of certain biochemical mediators (e.g., IL-1 beta , TNF alpha ) that can cause detrimental side effects, such as fever and inflammation.
机译：PCT号PCT / US93 / 07904 371日期1995年1月26日102（e）1995年1月26日的PCT申请1993年8月20日提交的PCT公布WO94 / 04163 PCT公开号1994年3月3日，本发明涉及在不刺激某些细胞因子产生的情况下发挥有效的和特异性的免疫学作用的中性的水溶性β-葡聚糖，涉及含有该新型β-葡聚糖的制剂，并涉及其新的制备方法。中性的水溶性β-葡聚糖制剂对人单核细胞的β-葡聚糖受体具有高亲和力，并保留了两种主要的生物学（或免疫）活性，（1）增强了吞噬细胞的杀菌活性，（2）单核细胞，中性粒细胞和血小板的造血活性。与现有技术中描述的可溶性葡聚糖不同，本发明的中性水溶性β-葡聚糖在体外和体内既不诱导也不引发IL-1β和TNFα的产生。本发明的中性水溶性β-葡聚糖的安全有效制剂可用于人和动物的治疗和/或预防性治疗方案，以增强其免疫反应，而无需刺激某些生化介质（例如IL- 1 beta，TNFα）会引起有害的副作用，例如发烧和发炎。

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