首页> 外国专利> Use of a PPAR agonist Alpha and PPAR gamma in preparing MedicinePPAR alpha and PPAR agonist compound and Method for Detecting range has agonist activity of PPAR alpha and PPAR gamma.

Use of a PPAR agonist Alpha and PPAR gamma in preparing MedicinePPAR alpha and PPAR agonist compound and Method for Detecting range has agonist activity of PPAR alpha and PPAR gamma.

机译：PPAR激动剂Alpha和PPARγ在制备MedicinePPARα和PPAR激动剂化合物以及检测范围的方法中的用途具有PPARα和PPARγ的激动剂活性。

页面导航

摘要
著录项
相似文献

摘要

Use of an agonist of the PPAR alpha and the PPAR gamma, or a pharmaceutically acceptable derivative thereof, to prepare a medicament useful for the treatment and / or prophylaxis of syndrome X in a human or non-human mammal, comprising an effective, non-toxic amount and pharmaceutically effective agonist and at least one pharmaceutically acceptable carrier; agonist of the PPAR alpha and the PPAR range;Pharmaceutical composition and method to detect a compound that has activist activity to both the PPAR alpha and the PPAR range. It is known that the isoform range of the receptor activated by protophylaxis prolliferators is PPAR range is a member of a nuclear receptor superfamily that includes receptors for hormones is teroids, thyroid and retinoids. It is known that the alpha isoform of the receptor activated by proliferators of peroxisomes PPAR alpha acts to stimulate peroxisomal proliferation in the rodent liver, which leads to an increased fatty oxidation by this organ.

机译：PPARα和PPARγ的激动剂或其药学上可接受的衍生物在制备可用于治疗和/或预防人类或非人类哺乳动物的X综合征的药物中的用途，该药物包括有效的，毒性量和药学上有效的激动剂以及至少一种药学上可接受的载体; PPARα和PPAR范围的激动剂;检测对PPARα和PPAR范围都具有激活剂活性的化合物的药物组合物和方法。已知由预防性催化剂激活的受体的同工型范围是PPAR范围，是核受体超家族的成员，该家族包括激素受体，类固醇，甲状腺和类维生素A。已知被过氧化物酶体PPARα的增殖剂激活的受体的α同工型起刺激啮齿动物肝脏中的过氧化物酶体增殖的作用，从而导致该器官的脂肪氧化增加。

著录项

公开/公告号AR005404A1

专利类型
公开/公告日1999-04-28

原文格式PDF
申请/专利权人 SMITHKLINE BEECHAM P.L.C.;
展开▼

申请/专利号AR1997P100087
发明设计人
展开▼

申请日1997-01-09
分类号A61K31/44;G01N33/15;A61K31;A61K31/42;A61K31/423;A61K31/4402;A61K45;A61P1;A61P3;A61P3/06;A61P3/10;A61P9;A61P9/10;A61P9/12;A61P13;A61P13/12;A61P43;C12N15/09;C12Q1/68;
国家 AR
入库时间 2022-08-22 02:28:26

相似文献

专利
外文文献
中文文献