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PERCUTANEOUSLY ABSORBABLE PREPARATION FOR LOCAL ANESTHESIA

机译:完全麻醉的局部麻醉准备

摘要

PROBLEM TO BE SOLVED: To obtain the subject preparation exhibiting sufficient anesthetic effect in a relatively short time through merely its application to the skin, by formulating a specific percutaneous absorption promoter in a rubber-based tack agent as a base for the preparation. ;SOLUTION: This percutaneously absorbable preparation for local anesthesia is obtained by formulating N-methyl 2-pyrrolidone as a percutaneous absorption promoter in a local anesthetic-contg. rubber-based tack agent composition layer on a substrate; wherein it is preferable that the rubber-based tackagent composition layer is also formulated with a compound selected from aliphatic alcohols each bearing 6-20C aliphatic hydrocarbon group and polyoxyethylene aliphatic ethers in addition to the N-methyl 2-pyrrolidone. The local anesthetic to be used is e.g. cocaine, procaine, chloroprocaine.;COPYRIGHT: (C)1999,JPO
机译:要解决的问题:通过在橡胶基增粘剂中配制特定的经皮吸收促进剂作为制剂的基础,从而仅通过将其施用到皮肤上就能够在较短的时间内获得表现出足够麻醉效果的主题制剂。 ;解决方案:通过将N-甲基2-吡咯烷酮配制成在局部麻醉剂中的经皮吸收促进剂,可获得这种用于局部麻醉的经皮吸收制剂。基材上的橡胶基增粘剂组合物层;其中,优选橡胶基增粘剂组合物层除了N-甲基2-吡咯烷酮以外,还由选自具有6〜20C脂肪族烃基的脂肪族醇和聚氧乙烯脂肪族醚的化合物构成。使用的局部麻醉剂例如为可卡因,普鲁卡因,氯普鲁卡因。;版权:(C)1999,日本特许厅

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