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Gene and protein applicable to the preparation of vaccines for rickettsia prowazekii and rickettsia typhi and the detection of both
Gene and protein applicable to the preparation of vaccines for rickettsia prowazekii and rickettsia typhi and the detection of both
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机译:适用于普氏立克次氏体和伤寒立克次氏体疫苗制备的基因和蛋白质以及两者的检测
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摘要
All or part of the DNA sequence of the gene which encodes the S- layer protein of R. prowazekii as illustrated in Sequence ID No. 1 as well as a truncated identical piece of this gene in R. typhi as well as the 5' and 3' noncoding regions can be used for vaccination against typhus and spotted fever rickettsial infection or to diagnose the diseases caused by these bacteria. The invention is also accomplished by the deduced amino acid sequence of the S-layer protein of R. prowazekii derived from the DNA sequence of the encoding gene. Further, the invention includes the peptide or protein products based on all or parts of this gene.
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