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Gene and protein applicable to the preparation of vaccines for rickettsia prowazekii and rickettsia typhi and the detection of both

机译:适用于普氏立克次氏体和伤寒立克次氏体疫苗制备的基因和蛋白质以及两者的检测

摘要

All or part of the DNA sequence of the gene which encodes the S- layer protein of R. prowazekii as illustrated in Sequence ID No. 1 as well as a truncated identical piece of this gene in R. typhi as well as the 5' and 3' noncoding regions can be used for vaccination against typhus and spotted fever rickettsial infection or to diagnose the diseases caused by these bacteria. The invention is also accomplished by the deduced amino acid sequence of the S-layer protein of R. prowazekii derived from the DNA sequence of the encoding gene. Further, the invention includes the peptide or protein products based on all or parts of this gene.
机译:序列编号1中所示的编码Prowazekii的S-层蛋白的基因的全部或部分DNA序列,以及在鼠伤寒沙门氏菌中的该基因的截短的相同片段以及5'和3'非编码区可用于预防斑疹伤寒和发烧的立克次氏体感染的疫苗或诊断由这些细菌引起的疾病。本发明还通过推导来源于编码基因的DNA序列的Prowazekii的S-层蛋白的氨基酸序列来完成。此外,本发明包括基于该基因的全部或部分的肽或蛋白质产物。

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