首页> 外国专利> 6-aryl-(methyl - or methylidone)-quinoline derivatives as voltage- gated potassium channel blockers

6-aryl-(methyl - or methylidone)-quinoline derivatives as voltage- gated potassium channel blockers

机译：6-芳基-（甲基或亚甲基酮）-喹啉衍生物作为电压门控钾通道阻滞剂

页面导航

摘要
著录项
相似文献

摘要

This invention concerns a compound of generic formula: ##STR1## or a pharmaceutically acceptable salt thereof, where the dotted lines represent optional bonds,PPR.sup.3 is an optionally substituted C. sub.6 -C.sub.10 aryl or heteroaryl group; optionally substituted by one or more substituents the same or different,P PR' represents one or more optional substituents the same or different, selected from the following: halogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.7 alkoxycarbonyl, C.sub.1 -C.sub.6 hydroxyalkyl, CN, aminocarbonyl, C.sub. 2 -C.sub.7 alkanoyloxy(C.sub.1 -C.sub.6 )alkyl, carboxy, C.sub.2 -C.sub. 7 alkanoxylamino, optionally substituted C.sub.6 -C.sub.10 or heteroaryl or an optionally substituted (C.sub.6 -C.sub.10 aryl)alkyl or a heteroaryl alkyl radical; andPPR" represents one or more optional mono- or di- valent substituents in the 5, 7 or 8 positions the same or different: monovalent substituents being selected from the following: C. sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.7 alkanoyloxy, hydroxy, amino, C. sub.2 -C.sub.7 alkanoylamino, C.sub.1 -C. sub.6 alkylamino, C.sub.1 -C. sub.6 hydroxalkyl, C.sub.7 -C.sub.17 aralkyloxyamino, R" can also represent hydroxy in the 6 position (when the optional bond is absent); the di-valent substituents being selected from oxo (i.e &boxH;O) and methylene (i.e &boxH;CH.sub.2);P P and the N-oxides thereof, which compounds have pharmaceutical uses conferred by their ability to block voltage gated potassium channels.

机译：本发明涉及一种通式为：的化合物或其药学上可接受的盐，其中虚线代表任选的键，P 3 R是任选取代的C.sub.6- C.sub.10芳基或杂芳基;任选地被一个或多个相同或不同的取代基取代，P> R'表示一个或多个相同或不同的可选取代基，其选自：卤素，C 1 -C 6烷基，C 2 -C 7烷氧羰基，C 1 -C 6羟烷基，CN，氨基羰基， 2 -C 7烷酰氧基（C 1 -C 6）烷基，羧基，C 2 -C 6。 7个烷氧基氨基，任选取代的C 6 -C 10或杂芳基或任选取代的（C 6 -C 10芳基）烷基或杂芳基烷基; “ P”和“ P”表示在5、7或8个相同或不同的位置上的一个或多个可选的单价或二价取代基：单价取代基选自：C.sub.1-C。 sub.6烷基，C.sub.2 -C.sub.7烷酰氧基，羟基，氨基，C.sub.2-C.sub.7烷酰基氨基，C.sub.C.sub.6烷基氨基，C。 sub.1-C.sub.6羟基烷基，C.sub.7-C.sub.17芳烷基氧基氨基，R“也可以在6位代表羟基（当不存在任选键时）;化合物，其二价取代基选自氧代（即＆boxH; O）和亚甲基（即＆boxH; CH.sub.2）;

及其N-氧化物，这些化合物因其能力而具有药物用途阻断电压门控钾通道。展开▼

著录项

公开/公告号US5753676A

专利类型
公开/公告日1998-05-19

原文格式PDF
申请/专利权人 CROSSLEY;ROGER;OPALKO;ALBERT;MEADE;PETER JONATHAN;IFILL;ANDERSON DECOURTNEY;BUSHELL;BRIAN JOHN;
展开▼

申请/专利号US19950448467
发明设计人 ROGER CROSSLEY;BRIAN JOHN BUSHELL;PETER JONATHAN MEADE;ALBERT OPALKO;ANDERSON DECOURTNEY IFILL;
展开▼

申请日1995-09-29
分类号C07D215/18;C07D215/54;A61K31/47;
国家 US
入库时间 2022-08-22 02:39:36

相似文献

专利
外文文献
中文文献