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N-aryl and N-heteroaryl-1,2-diaminocyclobutene-3,4-diones with smooth (N-Aryl and N-heteroaryl-1,2-diaminocyclobutene- muscle relaxing activities)
N-aryl and N-heteroaryl-1,2-diaminocyclobutene-3,4-diones with smooth (N-Aryl and N-heteroaryl-1,2-diaminocyclobutene- muscle relaxing activities)
A compound of formula (I) or a pharmaceutically acceptable salt thereof.;Wherein R 1 is hydrogen, C 1-10 linear or branched alkyl, C 3-10 cyclic or acyclic alkyl, C 2-7 alkanoyl, C 1-7 alkylsulfonyl, C 7-12 Arylalkanoyl having 9 to 20 carbon atoms, arylsulfonyl having 6 to 12 carbon atoms, arylalkanoyl having 8 to 12 carbon atoms or arylalkylsulfonyl having 7 to 12 carbon atoms; R 2 is hydrogen, C 1-10 linear or branched alkyl or C 3-10 cyclic or acyclic alkyl; A is a group Wherein R 7 and R 8 are independently of each other selected from the group consisting of cyano, nitro, amino, C 1-6 alkyl, C 1-6 perfluoroalkyl, C 1-6 alkoxy, C 1-6 perfluoroalkoxy, Amino, C 1-12 mono- or dialkylamino, sulfonamido, C 1-6 alkylsulfonamido, C 6-12 arylsulfonamido, C 2-6 alkylcarboxamido, C 7-12 arylcar carboxamide amido, C 1-6 alkylsulfonyl, C 1-6 alkylsulfonyl as a perfluoroalkyl, C 6-12 arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl, Carboxyalkoxy of 2 to 7 carbon atoms, hydroxyl or hydrogen), or A is Het is; Wherein R 9 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 perfluoroalkyl, C 1-6 alkoxy, C 1-6 perfluoroalkoxy, amino, C 1-12 mono- or dialkylamino , C 1-6 alkylsulfonamido, C 2-6 alkylcarboxamido, nitro, cyano, carboxyl, chloro, bromo, fluoro or iodo; n is an integer from 0 to 6; R 3 and R 4 are, independently of each other, hydrogen, C 1-10 linear or branched alkyl or C 3-10 cyclic or acyclic alkyl; C 1-10 perfluoroalkyl, C 1-10 hydroxyalkyl, C 2-10 alkoxyalkyl, fluoro; Or together form a spirocyclic ring having 3 to 7 total carbon atoms; R 5 and R 6 independently of each other are selected from the group consisting of cyano, nitro, amino, C 1-6 alkyl, C 1-6 perfluoroalkyl, C 1-6 alkoxy, C 1-6 perfluoroalkoxy, amino, C 1 - 12 mono- or dialkylamino, sulfonamide, C 1-6 alkyl sulfonamido, C 6-12 aryl sulfonamido, C 2-6 alkyl, carboxamido, C 7-12 aryl carboxamido , C 1-6 alkyl sulfonyl, alkyl sulfonyl, C 6-12 arylsulfonyl, chloro, bromo, fluoro C 1-6 perfluoroalkyl, iodo, 1-imidazolyl, carboxyl, C 2- 7 carboalkoxy, hydroxyl or hydrogen.
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