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Method and composition for promoting skin penetration of a drug using a penetration promoting agent when the drug and / or penetration promoting agent is unstable during long-term compound storage
Method and composition for promoting skin penetration of a drug using a penetration promoting agent when the drug and / or penetration promoting agent is unstable during long-term compound storage
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机译：当药物和/或渗透促进剂在长期化合物贮存期间不稳定时，使用渗透促进剂促进皮肤渗透的方法和组合物
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摘要
The present invention relates to a method for promoting epidermal, transdermal and dermal penetration of a topical pharmaceutical active agent (such as a drug or a medicament) which causes poor skin permeability in the absence of a penetration enhancer and causes decomposition due to instability during long-term storage with a specific penetration promoter, /RTI Also provided according to the present invention are methods and means for increasing the penetration of a pharmacologically active agent that destabilizes and degrades the penetration enhancer when the skin penetration rate is low and is compounded with a long-term skin penetrant. According to the present invention, one or more second compositions comprising at least one first composition containing a drug, a pharmaceutically acceptable salt thereof, a chemical derivative or combination thereof, and a penetration enhancer in an acceptable carrier, among the dermatologically acceptable carriers, . These compositions are physically isolated from each other until they are applied locally, simultaneously or in a short period of time to the body or skin surface, and are mixed and preferably formed into the final active composition on the skin. In addition, a premix of these compositions may be made according to the invention and applied to the skin. According to the present invention, the drug can be delivered in a therapeutically effective amount to the skin and systemic circulation system, and the penetration rate of the drug, which usually has poor skin penetration rate, can be remarkably increased by the action of the penetration promoter in the active composition.
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