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Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity
Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity
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机译：四：氢-β-咔啉衍生物的用途-用于制备具有抗转移活性或肿瘤侵袭或基质金属蛋白酶抑制活性的药物
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摘要
Use of beta -carboline derivatives of formula (I) and their enantiomers, reacemates, diastereomers and salts, for the preparation of pharmaceutical compositions having anti-metastatic activity or inhibitory activity of the tumour invasion process, is new. R = H, 1-5C alkyl, phenyl optionally substituted by 1-5C alkoxy, or (CH2)nCO2H; n = 1-3; R1 = H or CO2R4; R4 = H or 1-5C alkyl; R2 = H or CO2R4; and R3 = H, halo, 1-4C alkoxy or benzyloxy. Also claimed is use of (I) in compositions for treating or preventing conditions associated with the activity of the matrix metallo-proteinases.
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机译：式（I）的β-咔啉衍生物及其对映异构体，对映体，非对映异构体和盐在制备具有抗转移活性或抑制肿瘤侵袭过程活性的药物组合物中的用途是新的。 R ＝ H，1-5C烷基，任选地被1-5C烷氧基取代的苯基或（CH2）nCO2H; n = 1-3; R1 = H或CO2R4; R4 = H或1-5C烷基; R2 = H或CO2R4; R 3 ＝ H，卤素，1-4C烷氧基或苄氧基。还要求保护（I）在组合物中用于治疗或预防与基质金属蛋白酶活性有关的病症的用途。
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