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A method to provide a water-swellable, water-insoluble, highly hydrophilic polymer of a pharmaceutically active substance.
A method to provide a water-swellable, water-insoluble, highly hydrophilic polymer of a pharmaceutically active substance.
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机译：一种提供药物活性物质的水溶胀性，水不溶性，高亲水性聚合物的方法。
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摘要
A water-swellable, water-insoluble polymer is loaded with methylhydroxyprogesterone acetate (MAP) by: (a) preparing and grinding a mixture of a said polymer and MAP; or (b)(i) preparing a mixture of a said polymer which is stable under the heating to which the mixture is subjected in step (ii) and MAP and (ii) heating the mixture up to the melting temperature of MAP; or (c) swelling a said polymer with a MAP solution capable thereof and drying the resulting swollen polymer/MAP system. The MAP loaded polymer is useful as a pharmaceutical composition.
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