首页> 外国专利> Polynucleotide polynucleotide vector polynucleotide probe antibodies processes to detect the presence or absence of polynucleotide to detect polypeptides to triate candidate substances for anti-cancer therapy to treat cancer in a patient and to increase the susceptibility of cancer cells in a patient to cancer chemotherapy and/or radiotherapy and use of a candidate substance

Polynucleotide polynucleotide vector polynucleotide probe antibodies processes to detect the presence or absence of polynucleotide to detect polypeptides to triate candidate substances for anti-cancer therapy to treat cancer in a patient and to increase the susceptibility of cancer cells in a patient to cancer chemotherapy and/or radiotherapy and use of a candidate substance

机译：多核苷酸多核苷酸载体多核苷酸探针抗体的方法是检测多核苷酸的存在或不存在，以检测多肽来合成候选物质以进行抗癌治疗，以治疗患者的癌症并增加患者癌细胞对癌症化学疗法和/或癌症的敏感性。放射疗法和候选物质的使用

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摘要

This invention relates to a class of checkpoint genes and their polypeptide products which control progression through the cell cycle in eukaryotic cells. In particular this invention relates to Schizosaccharomyces pombe rad3 gene, to its human homologue (ATR) and to their encoded proteins. The invention further relates to assay methods for selecting compounds which modulate the activity of the polypeptide products of these checkpoint genes and the use of the selected compounds in anticancer therapy.

机译：本发明涉及控制真核细胞中整个细胞周期进程的检查点基因及其多肽产物。特别地，本发明涉及粟酒裂殖酵母rad3基因，其人同源物（ATR）及其编码的蛋白质。本发明进一步涉及用于选择调节这些检查点基因的多肽产物的活性的化合物的测定方法，以及所选择的化合物在抗癌治疗中的用途。

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公开/公告号BR9610168A

专利类型
公开/公告日1998-08-11

原文格式PDF
申请/专利权人 ICOS CORPORATION.;
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申请/专利号BR19989610168
发明设计人 ANTHONY MICHAEL CARR;
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申请日1998-03-06
分类号C12N15/54;C12N9/12;C12Q1/48;C12Q1/68;G01N33/50;C12N15/11;C07K16/40;A61K48/00;
国家 BR
入库时间 2022-08-22 02:58:35

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