There are described compounds of the formula CHEM where (a) X is O or S; (b) R is H, loweralkyl, CHEM where Y is O or S; R2 is loweralkyl, cycloalkyl, bicycloalkyl, cycloalkenyl, aryl, arylloweralkyl, heteroaryl or heteroarylloweralkyl, R3 is H or lower alkyl or the group -NR2R3 taken as a whole is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiomorpholinyl, 1-piperazinyl, 4-methyl-1-piperazinyl or 2-(2,6-dichlorophenylimino)-1-imidazolidinyl) and R4 is hydrogen, loweralkyl, arylloweralkyl, diarylloweralkyl, aryl or heteroaryl, (c) m is 1 or 2; (d) each Z is independently H, loweralkyl, halogen, nitro, -NH2, loweralkylcarbonylamino, arylcarbonylamino, loweralkoxycarbonylamino or loweralkylamino, and (e) R1 is H, loweralkyl, arylloweralkyl, heteroarylloweralkyl, cycloalkylmethyl or loweralkenylmethyl, with the proviso that when X is O, m is 1, Z is H and R1 is methyl, R is not -CONHCH3, -CONHC6H5, hydrogen, methyl or ethyl, and that when X is O, m is 1 and Z and R are both hydrogen, R is not hydrogen or methyl, and pharmaceutically acceptable acid addition salts thereof which are useful as memory-enhancing and analgesic agents.
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机译：描述了式的化合物，其中（a）X为O或S; （b）R为H，低级烷基，，其中Y为O或S; R 2为低级烷基，环烷基，二环烷基，环烯基，芳基，芳基低级烷基，杂芳基或杂芳基低级烷基，R 3为H或低级烷基，或-NR 2 R 3基团整体为1-吡咯烷基，1-哌啶基，4-吗啉基，4-硫代吗啉基， 1-哌嗪基，4-甲基-1-哌嗪基或2-（2,6-二氯苯基亚氨基）-1-咪唑啉基），R4为氢，低级烷基，芳基低级烷基，二芳基低级烷基，芳基或杂芳基，（c）m为1或2; （d）每个Z独立地为H，低级烷基，卤素，硝基，-NH 2，低级烷基羰基氨基，芳基羰基氨基，低级烷氧基羰基氨基或低级烷基氨基，和（e）R 1为H，低级烷基，芳基低级烷基，杂芳基低级烷基，环烷基甲基或低级链烯基甲基，条件是当X时是O，m为1，Z为H，R1为甲基，R不是-CONHCH3，-CONHC6H5，氢，甲基或乙基，当X为O时，m为1，Z和R均为氢，R为并非氢或甲基，及其药学上可接受的酸加成盐，它们可用作记忆增强和止痛剂。
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