Cell cycle-independent glioma cell surface antigen-specific human monoclonal antibody
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机译:不依赖细胞周期的神经胶质瘤细胞表面抗原特异性人类单克隆抗体
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摘要
The variable chains of two human monoclonal antibodies (HMAbs) of the IgM isotype are characterized by elucidation of cDNAs encoding those chains. The HMAbs are specific against cell cycle independent, glioma-associated antigen, and the antibodies do not recognize cultured normal human astrocytes. Immunoconjugates based on the sequences identified should target both proliferating and non-proliferating glioma cells in vivo, thus providing a valuable adjunctive therapy in the treatment of these tumors.
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