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Stable growth transformation of human T-lymphocytes by Herpesvirus saimiri (H. saimiri) subgroup C
Stable growth transformation of human T-lymphocytes by Herpesvirus saimiri (H. saimiri) subgroup C
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机译：疱疹病毒Saimiri（H. saimiri）C亚组对人T淋巴细胞的稳定生长转化
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摘要
The invention concerns the transformation of human T- lymphocytes to stable growth by infecting said T-cells with strains of H. saimiri subgroup NonA NonB, preferably subgroup C. The transformed cells grow independently of antigen stimulation and can have a phenotype of activated mature T-lymphocytes, expressing cell surface markers characteristic for the distinct differentiation status of the T-cells. Infection with strains of H. saimiri belonging to the subgroups above can thus be used to generate human T-cell lines for a variety of immunological and biochemical applications as well as for therapeutic use.
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