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Structure elucidation and synthesis of phenethylamides of the antineoplastic tetrapeptide Dolastatin 10
Structure elucidation and synthesis of phenethylamides of the antineoplastic tetrapeptide Dolastatin 10
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机译:抗肿瘤四肽Dolastatin 10苯乙酰胺的结构阐明和合成
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摘要
Dolastatin 10, a linear pentapeptide, has shown potent antineoplastic activity profiles against various experimental cancer systems. The design and synthesis of structural modifications of dolastatin 10 having significant antineoplastic activity against human cancer cell lines has been accomplished. Members of this group have demonstrated significant antineoplastic activity against selected human cancer cell lines. Especially: Ovarian OVCAR-3; Central Nervous System ("CNS") SF295; Renal A498; Lung NCI460; Colon KM20L2 and Melanoma SK-MEL-3.
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