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Structure elucidation and synthesis of phenethylamides of the antineoplastic tetrapeptide Dolastatin 10

机译:抗肿瘤四肽Dolastatin 10苯乙酰胺的结构阐明和合成

摘要

Dolastatin 10, a linear pentapeptide, has shown potent antineoplastic activity profiles against various experimental cancer systems. The design and synthesis of structural modifications of dolastatin 10 having significant antineoplastic activity against human cancer cell lines has been accomplished. Members of this group have demonstrated significant antineoplastic activity against selected human cancer cell lines. Especially: Ovarian OVCAR-3; Central Nervous System ("CNS") SF295; Renal A498; Lung NCI460; Colon KM20L2 and Melanoma SK-MEL-3.
机译:线性五肽Dolastatin 10对多种实验性癌症系统显示出有效的抗肿瘤活性。已经完成了针对人类癌细胞系具有显着抗肿瘤活性的dolastatin 10结构修饰的设计和合成。该组成员已证明对选定的人类癌细胞系具有显着的抗肿瘤活性。特别是:卵巢OVCAR-3;中枢神经系统(“ CNS”)SF295;肾脏A498;肺NCI460;冒号KM20L2和黑色素瘤SK-MEL-3。

著录项

  • 公开/公告号DE69308999T2

    专利类型

  • 公开/公告日1997-10-02

    原文格式PDF

  • 申请/专利权人 UNIV ARIZONA US;

    申请/专利号DE1993608999T

  • 发明设计人 PETIT GEORGE R US;BARKOCZY JOZSEF HU;

    申请日1993-12-03

  • 分类号C07K5/10;A61K38/07;

  • 国家 DE

  • 入库时间 2022-08-22 03:12:50

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