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Detecting antibodies against human papilloma virus proteins - for early diagnosis of HPV-mediated carcinoma

机译：检测针对人乳头瘤病毒蛋白的抗体-用于HPV介导的癌症的早期诊断

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摘要

Antibodies (Ab1) directed specifically against HPV (human papilloma virus) proteins (A) are detected in body fluids by: (i) incubating a native, carrier-bound (A) with the sample; and (ii) reacting bound Ab1 with: (a) labelled antibody (Ab2) directed against Ab1; or (b) unlabelled Ab2 and then third labelled antibody (Ab3) directed against Ab2. Also new are (A) made by refolding the corresponding denatured protein.

机译：通过以下方法在体液中检测到专门针对HPV（人乳头瘤病毒）蛋白（A）的抗体（Ab1）：（i）将与载体结合的天然（A）与样品一起孵育; （ii）使结合的Ab1与：（a）针对Ab1的标记抗体（Ab2）反应; （b）未标记的Ab2，然后是针对Ab2的第三标记的抗体（Ab3）。（A）也是新的，它是通过折叠相应的变性蛋白质制成的。

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公开/公告号DE19627031A1

专利类型
公开/公告日1997-01-09

原文格式PDF
申请/专利权人 DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS 69120 HEIDELBERG DE;
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申请/专利号DE1996127031
发明设计人 PAWLITA MICHAEL DR. 74927 ESCHELBRONN DE;FREY MANFRED DIPL.-CHEM. DR. 68259 MANNHEIM DE;VELHAGEN IRIS DIPL.-BIOL. DR. 68723 SCHWETZINGEN DE;ZENTGRAF HANSWALTER DIPL.-BIOL. DR. 69115 HEIDELBERG DE;MARTENS REGINA 69207 SANDHAUSEN DE;BRASPENNING JORIS A.C.J.M. DIPL.-BIOCHEM. 69436 SCHOENBRUNN DE;MESCHEDE WOLFGANG Z. DIPL.-BIOL. 69121 HEIDELBERG DE;
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申请日1996-07-04
分类号G01N33/543;C12Q1/70;G01N33/62;C07K14/01;G01N33/576;
国家 DE
入库时间 2022-08-22 03:14:47

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