首页> 外国专利> STRAIN OF RECOMBINANT SMALL POX VIRUS EXPRESSING STRUCTURAL PROTEINS OF THE HORSE VENEZUELAN ENCEPHALOMYELITIS VIRUS AND USEFUL FOR IMMUNOBIOLOGICAL PREPARATIONS PRODUCTION AND A METHOD OF ITS PREPARING

STRAIN OF RECOMBINANT SMALL POX VIRUS EXPRESSING STRUCTURAL PROTEINS OF THE HORSE VENEZUELAN ENCEPHALOMYELITIS VIRUS AND USEFUL FOR IMMUNOBIOLOGICAL PREPARATIONS PRODUCTION AND A METHOD OF ITS PREPARING

机译：表达马委内瑞拉脑脊髓炎病毒的结构蛋白的重组小痘病毒的菌株及其用于免疫生物学制备的方法及其制备方法

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FIELD: biotechnology. SUBSTANCE: strain is obtained by insertion of the sequence encoding only structural proteins of the horse Venezuelan encephalomyelitis virus (full-size DNA-copy of total 26 S RNA) in thymidine kinase gene of commercial small pox virus strain under control of small pox virus protein 7.5 K promoter. The obtained strain provides full-value immune response with respect to the horse Venezuelan encephalomyelitis virus. In cells infected with the obtained strain glycoproteins of supercapsid envelope of this virus were expressed on their surface. Strain can be used for diagnosis and prophylaxis of the horse Venezuelan encephalomyelitis virus. EFFECT: preparing the strain indicated above. 2 cl, 2 dwg, 2 tbl

机译：领域：生物技术。物质：通过在商业编码的小痘病毒蛋白的胸腺嘧啶激酶基因中插入仅编码马委内瑞拉脑脊髓炎病毒的结构蛋白的序列（总26 S RNA的全长DNA拷贝）而获得的菌株7.5 K启动子。所获得的菌株对马委内瑞拉脑脊髓炎病毒提供了全值的免疫反应。在用获得的菌株感染的细胞中，该病毒的超衣壳包膜的糖蛋白在其表面表达。菌株可用于诊断和预防马委内瑞拉脑脊髓炎病毒。效果：准备上述菌株。 2 cl，2 dwg，2 tbl

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公开/公告号RU2091489C1

专利类型
公开/公告日1997-09-27

原文格式PDF
申请/专利权人 GOSUDARSTVENNYJ NAUCHNYJ TSENTR VIRUSOLOGII I BIOTEKHNOLOGII VEKTOR;
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申请/专利号RU19930018105
发明设计人 FROLOV ILYA V;AGAPOV EVGENIJ V;KOLYKHALOV ALEKSANDR A;NETESOV SERGEJ V;SERPINSKIJ OLEG I;URMANOV ILNUR KH;SVYATCHENKO VIKTOR A;
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申请日1993-04-08
分类号C12N7/00;C12N15/33;C12N15/86;
国家 RU
入库时间 2022-08-22 03:15:43

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