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MEDICINAL AGENT AS OINTMENT FOR CUTANEOUS DISEASE AND CUTANEOUS MANIFESTATION OF IMMUNOLOGICALLY MEDIATED DISEASE TREATMENT AND/OR PROPHYLAXIS AND METHOD OF ITS SYNTHESIS
MEDICINAL AGENT AS OINTMENT FOR CUTANEOUS DISEASE AND CUTANEOUS MANIFESTATION OF IMMUNOLOGICALLY MEDIATED DISEASE TREATMENT AND/OR PROPHYLAXIS AND METHOD OF ITS SYNTHESIS
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机译：免疫介导的疾病治疗和/或前乳糜泻的皮肤病和皮肤病的膏药及其合成方法
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FIELD: organic chemistry and technology. SUBSTANCE: product: tricycle compound of the formula (I) where: adjacent pairs R1 and R2, R3, and R4, R5 and R6 form other bond with carbon atoms or they mean H; R2 can be lower alkyl; R7 - hydrogen, hydroxy-group, protected hydroxy-group, lower alkoxy-group; or R7 together with R1 form oxo-group; R8 - hydrogen or hydroxy-group; R9 - lower alkyl, alkenyl or lower alkyl substituted with oxo-group; R10-R17 - independently hydrogen or lower alkyl; R18 and R19 - independently R18aand hydrogen or R19aand hydrogen; R18a- hydroxy-group or lower alkoxy-group; R19a- hydroxy-group, lower alkoxy-group or protected hydroxy-group; n = 1 or 2; x1 and x2 - hydrogen or form together oxo-group; y1 - hydrogen or hydroxy-group; y2 - hydrogen or y1 and y2 form together oxo-group. Solubilizing agent and/or agent promoting impregnation: alkanediol, lower alkylene carbonate, alkanedicarboxylic acid ester, alkanecarboxylic acid glycerol ester, higher alkanecarboxylic acid alkyl ether, higher unsaturated alcohol and azacycloalkane. Ointment has tricycle compound or its pharmaceutically acceptable salt, solubilizing agent or agent promoting impregnation and ointment base taken at ratio, wt.-%: 0.01-10; 1-30 and the balance, up to 100%. Active component is dissolved in solubilizing agent or agent promoting impregnation, solution is mixed with an ointment base. EFFECT: improved method of synthesis, enhanced effectiveness of treatment and prophylaxis. 8 cl
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机译：领域：有机化学和技术。物质：产品：式（I）的三轮车化合物其中：相邻对R 1 和R 2 ，R 3 和R 4 ，R 5 和R < Sup> 6 与碳原子形成其他键或它们表示H; R 2 可以是低级烷基; R 7 -氢，羟基，被保护的羟基，低级烷氧基;或R 7 与R 1 一起形成氧代基团; R 8 -氢或羟基; R 9 -被氧代取代的低级烷基，烯基或低级烷基; R 10 -R 17 -独立地为氢或低级烷基; R 18 和R 19 -独立地为R18a和氢或R19a和氢; R18a-羟基或低级烷氧基; R19a-羟基，低级烷氧基或保护的羟基; n = 1或2; x 1 和x 2 -氢或一起形成氧代基团; y 1 -氢或羟基; y 2 -氢或y 1 和y 2 一起形成氧代基。增溶剂和/或促进浸渍的试剂：链烷二醇，低级碳酸亚烷基酯，链烷二羧酸酯，链烷羧酸羧酸甘油酯，高级链烷羧酸烷基醚，高级不饱和醇和氮杂环烷基。软膏具有三环化合物或其药学上可接受的盐，增溶剂或促进浸渍的试剂和软膏基质，其比例为重量％：0.01-10; 1-30，余额最高100％。活性成分溶解在增溶剂或促进浸渍的试剂中，溶液与软膏基质混合。效果：改进的合成方法，增强的治疗和预防效果。 8厘升
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