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The present invention relates to the use of an imidazole derivative including an angiotensin receptor AT1 and AT2, a specific product, a method for producing the same, a use thereof as a medicament, and a pharmaceutical composition containing the same as a medicament for use in the preparation of a medicament for inhibiting angiotensin receptor tyrosine kinase Products, Preparation Thereof, Use Thereof as Drugs, and Pharmaceutical Compositions Containing Same)
The present invention relates to the use of an imidazole derivative including an angiotensin receptor AT1 and AT2, a specific product, a method for producing the same, a use thereof as a medicament, and a pharmaceutical composition containing the same as a medicament for use in the preparation of a medicament for inhibiting angiotensin receptor tyrosine kinase Products, Preparation Thereof, Use Thereof as Drugs, and Pharmaceutical Compositions Containing Same)
The product of formula (I) below is an angiotensin II receptor ATOneAnd AT2/RTI is useful for providing a pharmaceutical composition for the treatment of disorders resulting from abnormal stimulation of RTI ID = 0.0 ;Wherein ROneIs especially alkyl, alkylthio or alkoxy; R2Is especially halogen,-S-R,-O-R or-C (OH) (R)-COOH, wherein R is alkyl or alkenyl; R3Is especially carboxy, acyl, halogen, alkyl, alkenyl or alkylthio; R4Especially-(CH2)ml-COOR14,-(CH2)ml-CONHR14,-(CH2)ml-CN,-SO2-NH-SO2-R14,-NH-SO2-R12,-PO3R14-NH-SO2-CF3, Wherein ml is 0-4 and R14Is hydrogen, alkyl or alkenyl.
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机译：以下式（I）的产物是血管紧张素II受体AT One 和AT 2 ，可用于提供药物组合物，用于治疗由异常刺激;其中R Sub尤其是烷基，烷硫基或烷氧基; R 2 尤其是卤素，-S-R，-O-R或-C（OH）（R）-COOH，其中R是烷基或烯基; R 3 尤其是羧基，酰基，卤素，烷基，烯基或烷硫基; R 4 特别是-（CH 2 ） ml -COOR 14 ，-（CH 2 ） ml -CONHR 14 ，-（CH 2 ） ml -CN，-SO 2 -NH-SO 2 -R 14 ，-NH-SO 2 -R 12 ，-PO 3 R 14 -NH-SO 2 -CF 3 ，其中ml为0-4， R 14 是氢，烷基或烯基。
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