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ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 RESTRICTED ANTIGEN PRESENTATION AND INHIBITORS THEREOF.
ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 RESTRICTED ANTIGEN PRESENTATION AND INHIBITORS THEREOF.
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机译:依赖于ATP-卵磷脂的蛋白水解在MHC-1限制性抗原表达中的作用及其抑制剂。
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摘要
Described herein are methods and drugs that inhibit the processing of antigens for presentation by major histocompatibility complex class I molecules. Specifically, inhibitors of the ATP-ubiquitin dependent proteolytic pathway are described, which can inhibit MHC-I antigen presentation. These methods and drugs may be useful for the treatment of autoimmune diseases and for reducing rejection of organs and graft transplants.
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