首页> 外国专利> Gene-targeted non-human mammals deficient in sod-1 gene and expressing humanized abeta sequence with swedish fad mutatio n

Gene-targeted non-human mammals deficient in sod-1 gene and expressing humanized abeta sequence with swedish fad mutatio n

机译:以基因为靶点的非人类哺乳动物,缺乏sod-1基因,并表达具有瑞典风尚突变的人源化abeta序列

摘要

Disclosed is non-human mouse homozygous for a targeted amyloid precursor protein-encoding gene comprising: (1) a human A beta peptide-encoding sequence in place of the native A beta peptide-encoding sequence; and (2) Swedish FAD mutations.
机译:公开了一种针对人的淀粉样前体蛋白编码靶基因的非人纯合子,其包含:(1)人Aβ肽编码序列代替天然Aβ肽编码序列; (2)瑞典FAD突变。

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