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Formulation of oral pharmaceuticals dosage process for the preparation of an enteric process-coated oral drug formulation to inhibit gastric acid secretion in mammals and human beings and use of an oral pharmaceutical formulation
Formulation of oral pharmaceuticals dosage process for the preparation of an enteric process-coated oral drug formulation to inhibit gastric acid secretion in mammals and human beings and use of an oral pharmaceutical formulation
A new oral pharmaceutical dosage form comprising a core material that contains a proton pump inhibitor, one or more alkaline reacting compounds and optionally pharmaceutical excipients having a water soluble separating layer and an enteric coating layer. The core material as such is alkaline reacting and the separating layer between the alkaline reacting core material and the enteric coating layer is formed in situ as a water soluble salt between the alkaline reacting compound(s) and the enteric coating polymer. The invention also describes a new efficient process for the manufacture of such a dosage form comprising two functionally different layers in one manufacturing step, and its use in medicine. IMAGE
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