首页> 外国专利> Purified form of streptogramins use a coccrystallised compound preparation process in purified form of streptogramins purification process of a group minority component to streptogramins purified component of group to streptogramins use one or more group components cocristalized compound streptograms and pharmaceutical composition

Purified form of streptogramins use a coccrystallised compound preparation process in purified form of streptogramins purification process of a group minority component to streptogramins purified component of group to streptogramins use one or more group components cocristalized compound streptograms and pharmaceutical composition

机译：链霉菌素的纯化形式使用链霉菌素的纯化形式的共结晶化合物的制备方法将少数族群成分转变为链霉菌素的过程的纯化过程链霉菌素的组纯化成分使用一种或多种组份的化合物化合物的链状结晶和药物组合物

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摘要

Co-crystalline mixture of (a) one or more group B components of streptogramins, of general formula: in which A* three eighths * is a radical of general formula: for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or, when R' is H, R can also represent -CH* superscript dot; dot above *, and R* three eighths * and R* subscript minus * are H, or alternatively A* three eighths * is a radical of formula: R is an isobutyl radical, and R* three eighths * is OH and R* subscript minus * is -CH* superscript dot; dot above *, and (b) one or more group A minority components of streptogramins, of general formula: in which R'' is H or a methyl or ethyl radical. Finely divided physical mixtures and co-precipitates of (a) and (b) are also claimed. A method of purifying the minority components of stretogramins by removal of Group B components from a cocrystallizate is claimed. Two components of Group A where R'' is hydrogen or ethyl are also claimed.

机译：（a）链霉菌素的一种或多种B组成分的共结晶混合物，其通式为：其中A *为八分之三*为通式的基团：其中R'为H或OH，Y为H，为甲基氨基自由基或二甲基氨基自由基，R为乙基，或当R'为H时，R还可以代表-CH *上标点; *上的点，并且R *八分之三*和R *下标*为H，或者A *八分之三*为下式的基团：R为异丁基，R *八分之三*为OH和R *下标负*是-CH *上标点; *和（b）一个或多个通式的链霉菌素A族少数组分，其中R”为H或甲基或乙基。还要求保护（a）和（b）的细分的物理混合物和共沉淀物。要求保护一种方法，该方法通过从共结晶物中除去B族组分来纯化石蜡蛋白的少数组分。还要求保护A组的两个组分，其中R”是氢或乙基。

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公开/公告号BR9408613A

专利类型
公开/公告日1997-09-16

原文格式PDF
申请/专利权人 RHONE-POULENC RORER S.A.;
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申请/专利号BR19949408613
发明设计人 PASCAL ANGER;BERTRAND BONNAVAUD;ALAIN GALLET;PATRICK LEFEVRE;
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申请日1994-08-12
分类号C07K5/078;C07K7/06;A61K38/05;A61K38/08;C07K5/06;
国家 BR
入库时间 2022-08-22 03:27:47

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