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Poly(2-hydroxyethyl methacrylate) and all copolymers of poly-HEMA fibers and cosmetic compositions containing same

机译:聚(甲基丙烯酸2-羟乙酯)和聚-HEMA纤维的所有共聚物以及含有该共聚物的化妆品组合物

摘要

Hydrogels are polymers that swell in water and are hydrophilic. The degree and nature of cross linking and the crystallinity of the polymer are responsible for its properties in the swollen state, and the degree to which it imbibes water without the loss of shape is important in many natural hydrogel. Some natural hydrogels are used in the textile industry, pulp and paper production, artificial silk, cellulosic membranes, and biomedical applications. Synthetic hydrogels are used in soft lenses, prosthetic materials and membranes for controlled drug delivery.P PPoly-HEMA (poly 2 hydroxylthyl methacrylate) is the most widely used hydrogel. The properties of poly HEMA can be modified by cross linking to a certain degree but its hydrophilicity can be increased by the introduction of a second hydroxyl using various monomers. Also its strength will also improve by the addition of a comonomer. These copolymers yielding increase hydrophilicity and strength are exhibited in soft hydrogel films, flexible even in the dry state. Copolymers of HEMA have been utilized in drug delivery systems where the drug diffusion is controlled by the type and ratios of comonomers used together with certain cross linking agents. Comonomers with anionic fixed charges are incorporated in poly HEMA chains, e.g. Methacylic acid (MAA) and acrylic acid(AA). The gels formed containing MAA used in soft contact lenses absorb much more protein than any other gels. Homopolymer poly HEMA fibers and various copolymers of poly HEMA have been combined with standard cosmetic, skin, and nail formulations to provide excellent, enhanced properties to the human body.
机译:水凝胶是在水中溶胀并且亲水的聚合物。交联的程度和性质以及聚合物的结晶性决定了其在溶胀状态下的性能,在许多天然水凝胶中,其吸收水而不失形的程度很重要。一些天然水凝胶用于纺织工业,纸浆和造纸,人造丝,纤维素膜和生物医学应用中。合成水凝胶可用于软晶状体,假体材料和膜中,以控制药物的输送。聚-HEMA(聚甲基丙烯酸2-羟乙酯)是使用最广泛的水凝胶。可以通过一定程度的交联来改变聚HEMA的性能,但是可以通过使用各种单体引入第二羟基来提高其亲水性。另外,通过添加共聚单体,其强度也将提高。这些共聚物在亲水性水凝胶薄膜中表现出增加的亲水性和强度,甚至在干燥状态下也具有柔性。 HEMA共聚物已用于药物递送系统,其中药物扩散由与某些交联剂一起使用的共聚单体的类型和比例控制。具有阴离子固定电荷的共聚单体并入聚HEMA链中,例如甲基丙烯酸(MAA)和丙烯酸(AA)。用于软性隐形眼镜的含有MAA的凝胶吸收的蛋白质比任何其他凝胶都要多。均聚聚HEMA纤维和聚HEMA的各种共聚物已与标准的化妆品,皮肤和指甲配方相结合,为人体提供了出色的增强特性。

著录项

  • 公开/公告号US5498407A

    专利类型

  • 公开/公告日1996-03-12

    原文格式PDF

  • 申请/专利权人 ATLAS;SHELDON M.;

    申请/专利号US19940328091

  • 发明设计人 SHELDON M. ATLAS;

    申请日1994-10-24

  • 分类号A61K7/035;A61K7/04;A61K7/027;

  • 国家 US

  • 入库时间 2022-08-22 03:38:58

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