首页> 外国专利> Enantiomeric cis-3- (4,6-dihydroxychroman-3-ylmethyl) benzoic acid (enantiomeric cis-3- (4,6-DIHYDROXYCHROMAN-3-YLMETHYL) BENZOIC ACIDS)

Enantiomeric cis-3- (4,6-dihydroxychroman-3-ylmethyl) benzoic acid (enantiomeric cis-3- (4,6-DIHYDROXYCHROMAN-3-YLMETHYL) BENZOIC ACIDS)

机译:对映异构体顺-3-(4,6-二羟基苯并-3-基甲基)苯甲酸(对映异构体顺-3-(4,6-二羟基苯甲基-3-甲苯基)苯甲酸)

摘要

The present invention relates to enantiomerically pure cis-3- (4,6-dihydroxychroman-3-ylmethyl) benzoic acid and a process for the preparation thereof. These compounds are optically pure mirror images of cis-3- (6-arylmethyloxy-4-hydroxychroman-3-ylmethyl) aniline sulfonamide useful for the treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related diseases. It is an intermediate compound useful for the preparation of isomers. More specifically, the present invention relates to (3R-cis) -3- (4,6-dihydroxychroman-3-ylmethyl) benzoic acid. The invention also relates to an improved process for the preparation of racemic cis-3- (4,6-dihydroxychroman-3 ylmethyl) benzoic acid.
机译:本发明涉及对映体纯的顺式(3-(4,6-二羟基苯并二氢吡喃-3-基)甲基)苯甲酸及其制备方法。这些化合物是可用于治疗哮喘,关节炎,牛皮癣,溃疡,心肌梗塞及相关疾病的顺式-3-(6-芳基甲氧基-4-羟基色氨酸-3-基甲基)苯胺磺酰胺的光学纯正镜像。它是用于制备异构体的中间体化合物。更具体地,本发明涉及(3R-顺式)-3-(4,6-二羟基苯并三-3-基甲基)苯甲酸。本发明还涉及制备外消旋顺式-3-(4,6-二羟基苯并三基甲基)苯甲酸的改进方法。

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