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1 - alkyl - 3 - (acylamino) - Epsilon caprolactamas Improvement of Learning and Memory and Pharmaceutical compositions containing them.

机译：1-烷基-3-（酰基氨基）-ε己内酰胺改善学习和记忆能力，以及包含它们的药物组合物。

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1 - alkyl - 3 - (acylamino) - caprolactamas formula (1). In which R is selected from the group consisting of pirolidin ONA - 1 - 2 - acetyl -, P - metoxibenzoilo.N - benziloxicarbonil - (S) - prolilo, fenilbutanoilo - trifluorometilbenzoilo, 3, 3, 4, 5 - trimetoxibenzoilo nicotinoilo, acyl, and that is between 1 and 5 Carbon ATOMS, and R Sub 1 is selected from the group consisting of hydrogen, metoxicarbonilmetilo, aminocarbonilmetilo, 2-hydroxyethyl and formilmeti I, (provided that if R is Hydrogen, sub 1,R is not Formilo or Acetyl) are potent Enhancers of Learning and Memory. The pharmaceutical compositions administered orally or parenterally In Unit dose comprise approximately between 100 and 500 mg of one of the compounds of formula (1).

机译：1-烷基-3-（酰基氨基）-己内酰胺式（1）。其中R选自吡咯烷酮ONA-1-2-乙酰基-，P-甲氧苯并噻吩基-N-苯并西卡西尔-（S）-脯氨酰，苯并丁那洛尔-三氟甲苯并苯并，3、3、4、5-曲美托苯并尼古丁，并且在1至5个碳原子之间，并且R Sub 1选自氢，甲氧羰基金属，氨基碳金属，2-羟乙基和for金属I，（前提是如果R是氢，则亚1，R不是福米洛或乙酰基）是有效的学习和记忆增强剂。以单位剂量口服或肠胃外给药的药物组合物包含约100至500mg的式（1）化合物之一。

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公开/公告号ES2081463T3

专利类型
公开/公告日1996-03-01

原文格式PDF
申请/专利权人 SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.;
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申请/专利号ES19910830276T
发明设计人 MISITI DOMENICO;TINTI MARIA ORNELLA;GIANNESSI FABIO;GHIRARDI ORLANDO;SCOLASTICO CARLO;COZZOLINO ROBERTO;
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申请日1991-06-20
分类号C07D223/12;A61K31/55;C07D403/12;
国家 ES
入库时间 2022-08-22 03:51:04

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