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METHOD OF OBTAINING FLAVANOLIGNANE PREPARATIONS OF ENHANCED LIBERATION AND RESORPTION POWER, FLAVANOLIGNANE PREPARATIONS OF ENHANCED LIBERATION AND RESORPTION POWER, AND THEIR APPLICATION IN PRODUCTION OF PHARMACEUTIC AGENTS
METHOD OF OBTAINING FLAVANOLIGNANE PREPARATIONS OF ENHANCED LIBERATION AND RESORPTION POWER, FLAVANOLIGNANE PREPARATIONS OF ENHANCED LIBERATION AND RESORPTION POWER, AND THEIR APPLICATION IN PRODUCTION OF PHARMACEUTIC AGENTS
The following are claimed: (A) prodn. of a flavano-lignan (FL) prepn. which has improved release properties compared to pure FL, comprising: (a1) prodn. of an aq.-alcoholic soln. of carriers and wetting agents, suspending an FL in this soln., and heating the resulting mixt. to boiling temp. to give a clear soln.; or (a2) suspending an FL and a wetting agent in alcohol, warming and stirring the suspension until a clear soln. is formed, treating this soln. with an aq. soln. of carriers, and heating and stirring the resulting mixt. until a clear soln. is formed; and (b) concentrating the clear soln. resulting from steps (a1) or (a2) until a coprecipitate is formed, then filtering and drying the coprecipitate. (B) Prepn. of a medicament for prophylactic and/or therapeutic treatment of liver disorders, comprising processing an FL prepn., which is in the form of a co-ppte. of an FL and at least one carrier (such as may be prepd. as described in (A) above) to a dosage form suitable for oral admin. Pref. the carrier is a water soluble sugar deriv. such as a mono- or disaccharide and/or a cellulose deriv. (such as sodium carboxymethyl starch, hydroxyethyl starch or carboxymethylcellulose), or is a linear polymer of 1-vinyl-2-pyrrolidone (such as polyvidone) for disperse systems. The wetting agent is polysorbate (such as polysorbate 80) or a sorbitan ester of a fatty acid.
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