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Compounded pharmaceutical composition and processes to treat AIDS to prevent HIV infection to prevent HIV infection to treat HIV infection and to inhibit HIV protease

机译：用于预防艾滋病的预防艾滋病毒感染的复合药物组合物和方法，用于预防艾滋病毒的治疗HIV感染和抑制HIV蛋白酶的化合物

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摘要

Compounds of formula IMAGE where R1 and R2 are independently hydrogen or optionally-substituted C1-4alkyl or aryl, or R1 and R2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of treating infection by HIV are also described.

机译：式的化合物是HIV蛋白酶抑制剂，其中R1和R2独立地为氢或任选取代的C1-4烷基或芳基，或R1和R2连接在一起形成单环或双环系统。这些化合物以化合物，药学上可接受的盐，药物组合物成分的形式，无论是否与其他抗病毒剂，免疫调节剂，抗生素或疫苗组合，都可用于治疗HIV感染和AIDS。还描述了治疗AIDS的方法和治疗HIV感染的方法。

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公开/公告号BR9406576A

专利类型
公开/公告日1996-01-30

原文格式PDF
申请/专利权人 MERCK & CO. INC.;
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申请/专利号BR19949406576
发明设计人 JOSEPH P VACCA;BRUCE D DORSEY;JAMES P GUARE;M KATHARINE HOLLOWAY;RANDALL W HUNGATE;RHONDA B LEVIN;
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申请日1994-04-26
分类号C07D217/26;C07D241/04;C07D409/12;C07D401/06;C07D207/16;C07D401/12;C07C237/20;C07D409/06;A61K31/47;A61K31/495;
国家 BR
入库时间 2022-08-22 03:54:49

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