首页> 外国专利> Compound immunogen processes to prevent fescue toxicosis in a herbivore to treat fescue toxicosis in a herbivore purified antibody hydridoma cell language and antibody

Compound immunogen processes to prevent fescue toxicosis in a herbivore to treat fescue toxicosis in a herbivore purified antibody hydridoma cell language and antibody

机译：化合物免疫原过程，以预防草食动物中的羊茅中毒，以草食动物纯化的抗体水肿瘤细胞语言和抗体治疗羊草中毒

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摘要

An immunogenic compound comprising the formula: IMAGE wherein X is selected from the group consisting of methyl and hydrogen; wherein R1 is a suitable functional group of the lysergic ring; wherein R2 is an immunogenic protein; and wherein Y is a bridge to link R1 to R2. Purified polyclonal and monoclonal antibodies specifically reactive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids are described. An antibody which is an anti-idiotype of the monoclonal antibody is provided. Methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention are provided.

机译：一种包含下式的免疫原性化合物：其中X选自甲基和氢;其中R1是麦角环的合适的官能团;其中R2是免疫原性蛋白质;其中Y是连接R1至R2的桥。描述了与免疫原性化合物特异性反应并与麦角肽碱和锁骨生物碱的麦角酸环反应的纯化的多克隆和单克隆抗体。提供了一种单克隆抗体的抗独特型的抗体。提供了利用本发明的免疫原性化合物和抗体预防和治疗羊茅中毒的方法。

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公开/公告号BR9405664A

专利类型
公开/公告日1996-04-30

原文格式PDF
申请/专利权人 UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC;UNITED STATED OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE;
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申请/专利号BR19949405664
发明设计人 NICOLAS S HILL;FREDERICK N THOMPSON JR;DONALD L DAWE;JOHN A STUDEMANN;
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申请日1994-01-21
分类号C07K4/10;C07K4/12;C07K101/00;A61K31/48;A61K38/03;A61K39/385;
国家 BR
入库时间 2022-08-22 03:54:53

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