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Poly medicine tolerance restrainers and revelation inhibiter
Poly medicine tolerance restrainers and revelation inhibiter
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机译：多元药物耐受性限制和启示抑制剂
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摘要
PURPOSE: To obtain a multidrug resistance inhibitor, capable of inhibiting the multidrug resistance and maintaining anticancer action essentially possessed by an anticancer agent without exhibiting any toxicity as in the case of Ca2+ antagonistic agents which have hitherto been used as the multidrug resistance inhibitor. ;CONSTITUTION: A multidrug resistance inhibitor containing a flavonoid or its pharmaceutically permissible salt, especially quercetin as an active ingredient in an amount of 0.01-99wt.%, preferably 0.1-80wt.%. Since the above-mentioned active ingredient is capable of inhibiting and suppressing the action of substances for inducing or enhancing the transcription and expression of a multidrug resistance gene (MDR1), the anticancer action essentially possessed by an anticancer agent can be maintained or enhanced. Since the above-mentioned gene MDR1 expressed in tumorous cells having the multidrug resistance is inhibited at a transcription level, the inhibitor has no toxicity as in the case of Ca2+ antagonistic agents. Furthermore, the dose of the multidrug resistance inhibitor is normally about 1-500mg per adult expressed as the amount of the quercetin and orally or parenterally administered in about 1-4 divided portions a day.;COPYRIGHT: (C)1993,JPO&Japio
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