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ACTINOMYCES BLONGING TO GENUS STREPTOMYCES AND TGF-BETA INHIBITOR DERIVED FROM THE SAME ACTINOMYCES
ACTINOMYCES BLONGING TO GENUS STREPTOMYCES AND TGF-BETA INHIBITOR DERIVED FROM THE SAME ACTINOMYCES
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机译：源自放线菌属的链霉菌和TGF-β1抑制剂的放线菌
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摘要
PURPOSE: To obtain the subject new actinomyces belonging to the genus Streptomyces, having TGF--inhibiting activity and capable of producing TGF- inhibiting active substance for treating diabetic nephropathy, acute glomerulonephritis, cirrhosis of the liver, pulmonary fibrosis, etc., caused by TGF-. CONSTITUTION: This actinomyces comprises actinomyces Streptomyces sp. NKK-908 (FERM P-14410) belonging to the genus Streptomyces, having gray- based aerial mycelium color, forming key-like or spiral spore chain in sporophore of aerial mycelium and having smooth surface of spore and capable of assimilating L-arabinose, D xylose, D-fructose, L-rhamnose, sucrose and raffinose on Pridham-Gottlieb agar culture medium and having TGF- inhibiting substance-producing ability. The actinomyces is cultured in a culture medium and then, a substance produced by the actinomyces is separated and collected from a cultured products to provide the objective TGF--inhibiting substance useful as a medicine for treating diabetic nephropathy, acute glomerulonephritis, cirrhosis of the liver, pulmonary fibrosis, etc., proliferative vitreous body retinopathy, etc., to which TGF- is related.
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