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DERIVATIVES OF 1,2,4-TRIAZOLE, OPTICALLY INERT OR CONTAINING R- OR S-CONFIGURATION AT C-2 AND C-3 ASYMMETRIC CENTERS, OR THEIR SALTS SHOWING FUNGICIDE ACTIVITY, AND A METHOD OF THEIR SYNTHESIS
DERIVATIVES OF 1,2,4-TRIAZOLE, OPTICALLY INERT OR CONTAINING R- OR S-CONFIGURATION AT C-2 AND C-3 ASYMMETRIC CENTERS, OR THEIR SALTS SHOWING FUNGICIDE ACTIVITY, AND A METHOD OF THEIR SYNTHESIS
FIELD: organic chemistry. SUBSTANCE: product: derivative of 1,2,4-triazole of the formula (I) where R°, R1 and R2-, are similar or different, hydrogen or lower alkyl group; A a group of the formula (II) where X chemical bond or a group of the formula (III) where X1 chemical bond or C1-C5-alkylene group which can contain sulfur atom; R5 and R6 are similar or different, hydrogen or lower alkyl group; R3 aromatic heterocycle in which heteroatom is nitrogen, sulfur or oxygen atom and which can be substituted with lower alkyl (unsubstituted or fluorine-substituted), C3-cycloalkyl, amini, lower alkylmercapto-group or oxo-group; n 0, 1 or 2; or A a group of the formula S-R4 where R4 as indicated above, Ro or R1 lower alkyl-group. Reagent 1: compound of the formula IV where R°, R1 and R2 as indicated above. Reagent 2: HS-X-R3 where X and R3 as indicated above. Reaction conditions: at temperature from -20 to 150 C at oxidation of reaction product if necessary. Synthesized compounds were used as antifungal agents. EFFECT: improved method of synthesis. 3 cl, 18 tbl
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机译：领域：有机化学。物质：产品：式（I）的1,2,4-三唑的衍生物<图像文件=“ 00000004.GIF” he =“ 35” id =“ imag0.4” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 67” />，其中R °，R 1 和R 2 -相似或不同，为氢或低级烷基;一组公式（II）其中X键或一组公式（III）其中X含硫原子的 1 化学键或C 1 -C 5 -亚烷基; R 5 和R 6 相似或不同，为氢或低级烷基; R 3 芳香杂环，其中杂原子为氮，硫或氧原子，并可被低级烷基（未取代或氟取代），C 3 -环烷基，阿米尼取代，低级烷基巯基或氧代基; n 0、1或2;或一组式SR 4 ，其中R 4 如上所示，R o 或R 1 低烷基。试剂1：式IV的化合物其中R °，R 1 和R 2 。试剂2：HS-X-R 3 其中X和R 3 如上所述。反应条件：如果需要，在-20至150℃的温度下使反应产物氧化。合成的化合物用作抗真菌剂。效果：改进的合成方法。 3厘升，18汤匙
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