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N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-11-tetraazacyclotetradecane derivatives and their metal complexes (Process for Producing N--Hydroxyalkyl-Tri-N-Carboxyalkyl-1,4,7,10-Tetraazacyclododecane and N--carboxyalkyl-1,4,8,11-tetraazacyclotetradecane Derivatives and Their Metal Complexes)
N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-11-tetraazacyclotetradecane derivatives and their metal complexes (Process for Producing N--Hydroxyalkyl-Tri-N-Carboxyalkyl-1,4,7,10-Tetraazacyclododecane and N--carboxyalkyl-1,4,8,11-tetraazacyclotetradecane Derivatives and Their Metal Complexes)
The present invention relates to a process for the preparation of 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane in the form of a possible salt, in the presence of a base, with an epoxide of general formula (II) In the presence of a base or in the presence of a base to react with a compound of the general formula (III) in the presence of a base or a solvent at a temperature of 0C to 220C for 0.5 to 48 hours, Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-Cyclotetradecane derivatives and their metal complexes.;Wherein ROneR2(CH RTI ID = 0.0 2)1-6-COOY; R2(A) is a group; n represents a number of 2 or 3; The present hydroxy moiety or carboxy group may be present in protected form.
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机译：本发明涉及一种在碱的存在下，用一种通常的环氧化物制备一种可能的盐形式的1,4,7,10-四氮杂环十二烷或1,4,8,11-四氮杂环十四烷的方法。式（II）在碱的存在下或在碱的存在下在碱或溶剂的存在下在0℃至220℃的温度下与通式（III）的化合物反应0.5至48小时，羟基烷基-三-N-羧基烷基-1,4,7,10-四氮杂十二烷和N-β-羟烷基-三-N-羧基烷基-1,4,7,10-环十二烷衍生物及其金属配合物; Sup>一个 R 2 （CH 2 ） 1-6 -COOY; R 2 （A）是一个基团; n表示2或3的数;本羟基部分或羧基可以被保护的形式存在。
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