首页>
外国专利>
The use of quinoline-3-carboxamide compounds for the treatment of diabetes (THE USE OF QUINOLINE-3-CARBOXAMIDE COMPOUNDS FOR TREATMENT OF DIABETES)
The use of quinoline-3-carboxamide compounds for the treatment of diabetes (THE USE OF QUINOLINE-3-CARBOXAMIDE COMPOUNDS FOR TREATMENT OF DIABETES)
The present invention relates to a method for the preparation of a composition for the treatment of symptoms associated with type 1 diabetes,1-9Diquinoline quinoline-3-carboxamide compound comprising structure I having a substituent for a compound of formula (I) or a salt of said compound (I).;(A) indicates that there are two conjugation double bonds between the atoms contained in the dashed line, (b) XOneAnd X2Is an oxygen atom or NH9Gt; X /RTI OneAnd X2H7Or H8Is added to the ring as a single bond and H7Or H8(C) H RTI ID = 0.0 1-9/RTI is hydrogen,9At least one XOneAnd X2Is NH9(D) H7And H8X /RTI of the quinoline ringOne, X2, And nitrogen atom (N).;Also described is a method of treating diabetes which administers the compound to a patient of the invention. Particularly preferred compounds in the present invention are N-phenyl-N-methyl-1, 2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide or its salts.
展开▼
机译:本发明涉及一种制备用于治疗与1型糖尿病有关的症状的组合物的方法,所述组合物包括具有结构I的化合物的取代基的 1-9 Sup>二喹啉喹啉-3-羧酰胺化合物。 (A)表示虚线所含原子之间有两个共轭双键,(b)X One Sub>和X 2 Sub>是一个氧原子或NH 9 Sup> Gt; X Sub> One Sub>和X 2 Sub> H 7 Sup>或H 8 Sup>被作为一个环添加到环中键和H 7 Sup>或H 8 Sup>(C)H 1-9 Sup>是氢, 9 Sup>至少一个X 1 Sub>和X 2 Sub>是NH 9 Sup>(D)H 7 Sup>并且喹啉环 One Sub>,X 2 Sub>和氮原子(N)的H 8 Sup> X>;也描述为向本发明的患者施用化合物的治疗糖尿病的方法。本发明中特别优选的化合物是N-苯基-N-甲基-1、2-二氢-4-羟基-1-甲基-2-氧代喹啉-3-羧酰胺或其盐。
展开▼