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首页> 外国专利> New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions which contain them the invention relates to perhydroisoindole derivatives of general formula (I), and their salts when they exist advantageously as neurokinin A antagonists.

New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions which contain them the invention relates to perhydroisoindole derivatives of general formula (I), and their salts when they exist advantageously as neurokinin A antagonists.

机译：本发明的新的全氢异吲哚衍生物，其制备以及包含它们的药物组合物涉及通式（I）的全氢异吲哚衍生物及其盐，当它们有利地作为神经激肽A拮抗剂存在时。

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摘要

A perhydroisoindole derivative of general formula (I) in which the radicals R are the same and are phenyl radicals which may be substituted with a methyl radical in the 2- or 3-position, R1 is an optionally substituted phenyl or a cyclohexadienyl, naphthyl or indenyl radical or a heterocyclic radical which may be substituted, R2 is H, or alkyl and R3 is phenyl which may be substituted in the 2-position with an alkyl or alkoxy containing 1 or 2 carbon atoms, and a salt thereof (when it exists).
机译：通式（I）的全氢异吲哚衍生物，其中基团R是相同的，并且是可以在2-或3-位被甲基取代的苯基，R1是任选取代的苯基或环己二烯基，萘基或可以被取代的茚基或杂环基，R 2是H或烷基，R 3是可以在2-位被含1或2个碳原子的烷基或烷氧基取代的苯基，及其盐（存在时） ）。

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