首页> 外国专利> Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process.

Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process.

机译:取代二氢异喹啉酮和相关化合物,以增强辐射和某些化学治疗剂的致死作用;选择的化合物,类似物和方法。

摘要

The invention is selected, novel, and known analogs of isoquinolinones of the formula CHEM and pharmaceutically acceptable salts thereof; novel pharmaceutical compositions; and a method for enhancing the lethal effects for tumor cells to treatment having DNA damaging activity such as ionizing radiation or with chemotherapeutic agents.
机译:本发明是式的异喹啉酮及其药学上可接受的盐的选择的,新颖的和已知的类似物;新的药物组合物;以及增强对肿瘤细胞的致死作用的方法,该致死作用具有电离辐射或化学治疗剂等具有DNA破坏活性的治疗。

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