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EXTRACT EXHIBITING INHIBITION ACTIVITY ON THROMBIN, PROCESS OF ITS PREPARATION, POLYPEPTIDE PREPARED FROM THIS EXTRACT, PROCESS OF ITS PREPARATION, A PHARMACEUTICAL PREPARATION BASED ON SAID POLYPEPTIDE, THE USE OF THE POLYPEPTIDE FOR THE PREPARATION OF THE PHARMACEUTICAL PREPARATION AND USE OF RHYNCHOBDELLIDA STRAIN LEECHES
EXTRACT EXHIBITING INHIBITION ACTIVITY ON THROMBIN, PROCESS OF ITS PREPARATION, POLYPEPTIDE PREPARED FROM THIS EXTRACT, PROCESS OF ITS PREPARATION, A PHARMACEUTICAL PREPARATION BASED ON SAID POLYPEPTIDE, THE USE OF THE POLYPEPTIDE FOR THE PREPARATION OF THE PHARMACEUTICAL PREPARATION AND USE OF RHYNCHOBDELLIDA STRAIN LEECHES
PCT No. PCT/EP94/01404 Sec. 371 Date Jan. 5, 1995 Sec. 102(e) Date Jan. 5, 1995 PCT Filed May 3, 1994 PCT Pub. No. WO94/26777 PCT Pub. Date Nov. 24, 1994The invention relates to novel polypeptides with antithrombin activity obtainable from extracts of tissues or secretions of leeches of the order Rhynchobdellida, particularly of the species Theromyzon tessulatum. The polypetides have molecular weights of about 14 kD, 9 kD and 3 kD and can be used in pharmaceutical compositions for the treatment of thrombosis related disorders and events.
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